Aim - to increase the effectiveness of anticancer vaccine delivery and activity via its immobilization on reconstructed chromatin (RC). The hybrid mice of CDF-1 line with transplanted P-388 leukemia were used. Reconstructed chromatin was obtained from the thymus of inbred rats. Glycopeptide cancer vaccine prepared from P-388 leukemia cells, was immobilized of RC. Zeta-potential of tbyraocytes from tumor-bearing mice was calculated from Smoluchowski equation. The data have demonstrated the principal possibility of using the fragments of reconstructed chromatin of heterologous origin as a carrier of glycopeptide cancer vaccine prepared from the cells of P-388 leukemia. Preventive immunization with the correspondingly immobilized vaccine normalized zeta-potential of thymocytes in animals with transplanted P-388 leukemia. Conclusions: the use of immobilization of glycopeptide cancer vaccine on reconstructed chromatin improves anticancer activity of the vaccination.

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